Small-molecule NNMT inhibitor; not a peptide

5-Amino-1MQ

NNMT

5-Amino-1MQ is a cell-permeable NNMT inhibitor often sold alongside peptides, although chemically it is not a peptide. Evidence for changes in fat mass, liver fat and metabolic markers comes almost entirely from animal studies.

1Overview
Reference frequency
DataMouse models and pharmacology
Research status

Preclinical only

Velora 5-Amino-1MQ vial
5-AMINO-1MQ10 MG
01 · Overview

What is 5-Amino-1MQ?

5-Amino-1MQ is a cell-permeable NNMT inhibitor often sold alongside peptides, although chemically it is not a peptide. Evidence for changes in fat mass, liver fat and metabolic markers comes almost entirely from animal studies.

Research route, formulation and population determine what a result actually means.

01

NNMT

Inhibits NNMT, an enzyme in nicotinamide and methyl-group metabolism.

02 · Research

What do the studies show?

Mouse models and pharmacology. Educational information. Not diagnosis, treatment or use advice.

Cells/mice
Preclinical

NNMT inhibition

In adipocytes, 5-Amino-1MQ reduced the NNMT product 1-MNA and altered, among other things, NAD+ and SAM levels. In diet-induced obesity models, body weight and white-fat mass fell; this is preclinical evidence.

0
Limited evidence

No clinical efficacy data

Animal doses cannot be converted into a safe or effective human dose.

03 · DATA

Peptide and product specifications

Checked identity data for this research compound or blend.

5-Amino-1MQPeptide and product specifications
Molecular formula
C₁₀H₁₁IN₂ (iodide salt)
Molecular weight
286.11 g/mol (iodide salt); 159.21 g/mol free base
CAS number
42464-96-0
Purity
Batch-specific — confirm identity and purity with the Velora COA
Reference form
White lyophilised powder
Reference diluent
Formulation- and batch-specific; there is no universal diluent for every research compound
Unreconstituted-material storage
Follow the accompanying COA, product label and validated stability data

These are compound references, not a batch certificate. Purity and identity of a specific Velora batch must be confirmed by its accompanying COA and laboratory report.

04 · Calculator

Reconstitution and U-100 conversion

This module only converts concentration and volume. Inputs are not recommendations or individual dosing advice.

Calculator

Not established; animal-study protocols only

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0.00 mL
5-Amino-1MQ vial
5-AMINO-1MQ
10 MG
Concentration
Per unit
Complete amounts
Calculated duration
LAB · RECONSTITUTION

How to reconstitute 5-Amino-1MQ for laboratory research

A visual workflow for controlled laboratory reconstitution. Always follow the product label, COA and a validated protocol.

Five visual laboratory reconstitution steps: clean, measure diluent, add slowly, swirl gently and store according to protocol.
1

Clean

Disinfect the rubber closures of both vials and allow them to dry.

2

Measure diluent

Withdraw only the diluent validated for the specific compound.

3

Add slowly

Let the liquid run slowly down the inside wall of the vial.

4

Swirl gently

Do not shake; rotate gently until the material has dissolved.

5

Store per protocol

Follow the product label, COA and validated stability data.

Important checks before and after reconstitution

Check the product

First confirm that the product is a lyophilised vial. Prefilled pens and ready-to-use solutions do not require reconstitution. Check the label, COA and specified diluent.

Use clean, sterile technique

Wash your hands, clean the work surface and use new sterile equipment for every procedure. Clean both rubber closures with separate alcohol swabs and let them dry completely.

Concentration, not total amount

The volume of liquid added changes the concentration in mg per mL, but not the total amount of research compound in the vial. Use the calculator to check this in advance.

Inspect and label

Check for unexpected discoloration, cloudiness or visible particles. Record the compound, concentration and reconstitution date. Storage time and temperature are product-specific; a fixed 28-day rule does not apply to every compound.

General reconstitution volumes listed by the source

General examples, not a product-specific protocol. The chosen volume determines concentration; always check the label, COA and calculator.

Vial strengthCommonly listed volume
2 mg1–2 mL
5 mg2–3 mL
6 mg2–3 mL
10 mg2–4 mL
15 mg3–5 mL
20 mg4–8 mL

Practical background source: Free Medical Journals — Complete Step-by-Step Guide to Peptide Reconstitution, accessed July 2026. This is a secondary educational source; the product label, COA and validated stability data remain authoritative.

05 · Safety and limitations

Safety and limitations

Research route, formulation and population determine what a result actually means.

What is known

  • Visible research claims use primary or official sources.
  • The calculator is arithmetic and does not turn a study amount into medical advice.
  • A registered medicine and a research vial are not automatically equivalent.

What remains uncertain

  • Many products lack long-term safety data and independent replication.
  • Animal and cell findings do not predict a safe human dose.
  • Stability depends on formulation, pH, sterility, light, temperature and packaging.
Status: Preclinical only. Educational information. Not diagnosis, treatment or use advice.
06 · FAQ

Frequently asked questions

5-Amino-1MQ is a cell-permeable NNMT inhibitor often sold alongside peptides, although chemically it is not a peptide. Evidence for changes in fat mass, liver fat and metabolic markers comes almost entirely from animal studies.
In adipocytes, 5-Amino-1MQ reduced the NNMT product 1-MNA and altered, among other things, NAD+ and SAM levels. In diet-induced obesity models, body weight and white-fat mass fell; this is preclinical evidence. Animal doses cannot be converted into a safe or effective human dose.
No. It performs arithmetic conversions only. Medical decisions belong with a licensed healthcare professional.
The curve follows the agreed storage model and is not a laboratory result.
2–8 °C. Protect from light and repeated freeze-thaw cycles.
07 · Sources

Primary research sources

Educational information. Not diagnosis, treatment or use advice.

Selective and membrane-permeable small-molecule inhibitors of NNMT reverse high-fat-diet-induced obesity in mice Biochemical Pharmacology, 2018. Link
Combined NNMT inhibition and reduced-calorie diet normalizes body composition in obese mice Scientific Reports, 2021. Link